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David Goldstein

David B. Goldstein, Ph.D.
Director, Center for Human Genome Variation
The Richard and Pat Johnson Distinguished University Professor
 

Dr. David Goldstein is Professor of Molecular Genetics & Microbiology, Professor of Biology and Director of the Center for Human Genome Variation at Duke University. He received his Ph.D. in Biological Sciences from Stanford University in 1994, and from 1999-2005 was Wolfson Professor of Genetics at University College London. In April 2007, he was appointed Honorary Professor, Institute of Neurology, University College London, UK.

Dr. Goldstein is the author of over 200 scholarly publications in the areas of population and medical genetics. His principal interests include human genetic diversity, the genetics of disease, and pharmacogenetics. He is the recipient of one of the first seven nationally awarded Royal Society / Wolfson research merit awards in the UK for his work in human population genetics. Dr. Goldstein was awarded the Triangle Business Journal Health Care Heroes Award: Innovator/Researcher Award, March 2008.

Selected Publications

Goldstein DB. Growth of genome screening needs debate. Nature. 2011 Aug 3;476(7358):27-8. doi: 10.1038/476027a.
PMID:21814258 

Cirulli ET, Heinzen EL, Dietrich FS, Shianna KV, Singh A, Maia JM, Goedert JJ, Goldstein DB. A whole-genome analysis of premature termination codons. Genomics. 2011 Jul 22. PMID:21803148 

Cirulli ET, Attix DK, Smith PJ, Chiba-Falek O, Pennuto TO, Linney KN, Goldstein DB. Contribution of Pastimes and Testing Strategies to the Performance of Healthy Volunteers on Cognitive Tests. Clin Neuropsychol. 2011 Jul 4. [Epub ahead of print] PubMed PMID: 21722049 

Ge D, Ruzzo EK, Shianna KV, He M, Pelak K, Heinzen EL, Need AC, Cirulli ET, Maia JM, Dickson SP, Zhu M, Singh A, Allen AS, Goldstein DB. SVA: Software for Annotating and Visualizing Sequenced Human Genomes. Bioinformatics. 2011 May 29. [Epub ahead of print] PubMed PMID: 21624899 PMCID:PMC3129530
 
Zhu Q, Ge D, Maia JM, Zhu M, Petrovski S, Dickson SP, Heinzen EL, Shianna KV Goldstein DB. A Genome-wide Comparison of the Functional Properties of Rare and Common Genetic Variants in Humans. Am J Hum Genet. 2011 Apr 8;88(4):458-68. Epub 2011 Mar 31. PubMed PMID:21457907; PubMed Central PMCID: PMC3071924
 
Fellay J, Frahm N, Shianna KV, Cirulli ET, Casimiro DR, Robertson MN, Haynes BF, Geraghty DE, McElrath MJ, Goldstein DB; for the National Institute of Allergy and Infectious Diseases (NIAID) Center for HIV/AIDS Vaccine Immunology (CHAVI) and the NIAID HIV Vaccine Trials Network (HVTN). Host Genetic Determinants of T Cell Responses to the MRKAd5 HIV-1 gag/pol/nef Vaccine in the Step Trial. J Infect Dis. 2011 Jan 28. [Epub ahead of print] PubMed PMID: 21278214. PubMed Central PMCID: PMC3071133
 
Goldstein DB. The Importance of Synthetic Associations Will Only Be Resolved Empirically. PLoS Biol. 2011 Jan 18;9(1):e1001008. PubMed PMID: 21267066. PMCID:PMC3022532
 
Hitomi Y, Cirulli ET, Fellay J, McHutchison JG, Thompson AJ, Gumbs CE, Shianna KV, Urban TJ, Goldstein DB. Inosine triphosphate protects against ribavirin-induced ATP loss by restoring adenylosuccinate synthase function. Gastroenterology. 2010 Dec 31; PubMed PMID:21199653 
 
Pelak K, Shianna KV, Ge D, Maia JM, Zhu M, Smith JP, Cirulli ET, Fellay J, Dickson SP, Gumbs CE, Heinzen EL, Need AC, Ruzzo EK, Singh A, Campbell CR, Hong LK, Lornsen KA, McKenzie AM, Sobreira NL, Hoover-Fong JE, Milner JD, Ottman R, Haynes BF, Goedert JJ, Goldstein DB. The characterization of twenty sequenced human genomes. PLoS Genet. 2010 Sep 9;6(9). pii: e1001111. PubMed PMID: 20838461; PubMed Central PMCID: PMC2936541

Goldstein DB, Noor MA. Genomics: Lessons in complexity from yeast. Nature 2010, Apr 15;464(7291):985-6
Contact Information:

David B. Goldstein
Center for Human Genome Variation
Duke University
308 Research Drive, Box 91009
LSRC B Wing, Room 330
Durham, NC 27708
(P) 919-684-0896

 

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