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Erin Heinzen

Erin L. Heinzen, Ph.D.is an Assistant Research Professor.  She received her Doctorate of Pharmacy in 2001,  follwed by a Ph.D. in pharmacokinetics/pharmacodynamics in 2004 from the University of North Carolina at Chapel Hill. She subsequently completed postdoctoral training studying receptor pharmacology at UNC Chapel Hill. Prior to joining the faculty in 2009, Dr. Heinzen was a postdoctoral fellow in the lab of Professor David Goldstein. Her research focuses on the impact of genetic variation on the brain transcriptome and how genetic regulation of gene expression may contribute to neuropsychiatric disease. She is specifically interested in studying how rare epilepsy-causing genetic variants may regulate the brain transcriptome to contribute to epilepsy pathophysiology.

Erin Heinzen

 

 

 

 

 

 

 

CHGV Epilepsy Research Program

Selected Publications

Cirulli ET, Heinzen EL, Dietrich FS, et al. A whole-genome analysis of premature termination codons. Genomics. 2011 Jul 22. PMID:21803148

Catarino CB, Kasperavičiūtė D, Thom M, Cavalleri GL, Martinian L, Heinzen EL, Dorn T, Grunwald T, Chaila E, Depondt C, Krämer G, Delanty N, Goldstein DB, Sisodiya SM. Genomic microdeletions associated with epilepsy: Not a contraindication to resective surgery. Epilepsia. 2011 Jun 2. doi: 10.1111/j.1528-1167.2011.03087.x. PubMed PMID: 21635232

Ge D, Ruzzo EK, Shianna KV, He M, Pelak K, Heinzen EL, Need AC, Cirulli ET, Maia JM, Dickson SP, Zhu M, Singh A, Allen AS, Goldstein DB. SVA: Software for Annotating and Visualizing Sequenced Human Genomes. Bioinformatics. 2011 May 29. [Epub ahead of print] PubMed PMID: 21624899

Zhu Q, Ge D, Maia JM, Zhu M, Petrovski S, Dickson SP, Heinzen EL, Shianna KV, Goldstein DB. A Genome-wide Comparison of the Functional Properties of Rare and Common Genetic Variants in Humans. Am J Hum Genet. 2011 Apr 8; 88 (4) :458-68. PubMed PMID:21457907

McCormack M, Alfirevic A, Bourgeois S, Farrell JJ, Kasperavičiūtė D, Carrington M, Sills GJ, Marson T, Jia X, de Bakker PI, Chinthapalli K, Molokhia M, Johnson MR, O'Connor GD, Chaila E, Alhusaini S, Shianna KV, Radtke RA, Heinzen EL, Walley N, Pandolfo M, Pichler W, Park BK, Depondt C, Sisodiya SM, Goldstein DB, Deloukas P, Delanty N, Cavalleri GL, Pirmohamed M. HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. N Engl J Med. 2011 Mar 24; 364 (12) :1134-43. PubMed PMID:21428769.

Pelak K, Shianna KV, Ge D, Maia JM, Zhu M, Smith JP, Cirulli ET, Fellay J, Dickson SP, Gumbs CE, Heinzen EL, Need AC, Ruzzo EK, Singh A, Campbell CR, Hong LK, Lornsen KA, McKenzie AM, Sobreira NL, Hoover-Fong JE, Milner JD, Ottman R, Haynes BF, Goedert JJ, Goldstein DB. The characterization of twenty sequenced human genomes. PLoS Genet. 2010 Sep 9;6(9). pii: e1001111. PubMed PMID: 20838461; PubMed Central PMCID: PMC2936541.

Pelak K, Shianna KV, Ge D, Maia JM, Zhu M, Smith JP, Cirulli ET, Fellay J, Dickson SP, Gumbs CE, Heinzen EL, Need AC, Ruzzo EK, Singh A, Campbell CR, Hong LK, Lornsen KA, McKenzie AM, Sobreira NL, Hoover-Fong JE, Milner JD, Ottman R, Haynes BF, Goedert JJ, Goldstein DB. The characterization of twenty sequenced human genomes. PLoS Genet. 2010 Sep 9;6(9). pii: e1001111. PubMed PMID: 20838461; PubMed Central PMCID: PMC2936541.

Kasperaviciute D, Catarino CB, Heinzen EL, Depondt C, Cavalleri GL, Caboclo LO, Tate SK, Jamnadas-Khoda J, Chinthapalli K, Clayton LM, Shianna KV, Radtke RA, Mikati MA, Gallentine WB, Husain AM, Alhusaini S, Leppert D, Middleton LT, Gibson RA, Johnson MR, Matthews PM, Hosford D, Heuser K, Amos L, Ortega M, Zumsteg D, Wieser HG, Steinhoff BJ, Krämer G, Hansen J, Dorn T, Kantanen AM, Gjerstad L, Peuralinna T, Hernandez DG, Eriksson KJ, Kälviäinen RK, Doherty CP, Wood NW, Pandolfo M, Duncan JS, Sander JW, Delanty N, Goldstein DB, Sisodiya SM. Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study. Brain. 2010 Jun 3. [Epub ahead of print] PubMed PMID: 20522523.

Rotger M, Dang KK, Fellay J, Heinzen EL, Feng S, Descombes P, Shianna KV, Ge D, Günthard HF, Goldstein DB, Telenti A; Swiss HIV Cohort Study; Center for HIV/AIDS Vaccine Immunology. Genome-wide mRNA expression correlates of viral control in CD4+ T-cells from HIV-1-infected individuals. PLoS Pathog. 2010 Feb 26;6(2):e1000781. PubMed PMID: 20195503; PubMed Central PMCID: PMC2829051.

Cirulli ET, Singh A, Shianna KV, Ge D, Smith JP, Maia JM, Heinzen EL, Goedert JJ, Goldstein DB; Center for HIV/AIDS Vaccine Immunology (CHAVI). Screening the human exome: a comparison of whole genome and whole transcriptome sequencing. Genome Biol. 2010;11(5):R57. Epub 2010 May 28. PubMed PMID: 20598109; PubMed Central PMCID: PMC2898068.

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