Postdoctoral Associates

 
Yujun Han
Gabi Griffin
 
Gabi is interested in epilepsy genetics. She has broad experience in analyzing the genetic causes of complex and Mendelian neurological diseases in humans using both bioinformatics approaches and molecular biology techniques.  She completed her doctoral training in Genetics and Molecular Biology at the University of North Carolina-Chapel Hill.
  
Yujun Han
Matt Halvorsen
 
Matt received his PhD in Bioinformatics and Computational Biology from the University of North Carolina at Chapel Hill, and joined the CHGV in January 2013.   He focuses on using genetic variants in cases with neurological disorders to identify genes whose dysfunction is involved in the resultant phenotype, as well as advancing the interpretation and prioritization of noncoding genetic variants.

 

Selected Publications 

  1. Martin JS*, Halvorsen M*, Davis-Neulander L, Ritz J, Gopinath C, et al. (2012). Structural effects of linkage disequilibrium on the transcriptome. RNA 18: 77-87.
  2. Pelleymounter LL, Moon I, Johnson JA, Laederach A, Halvorsen M, Eckloffd B, Aboa R, Rossettie S (2011). A novel application of pattern recognition for accurate SNP and indel discovery from high-throughput data: targeted resequencing of the glucocorticoid receptor co-chaperone FKBP5 in a Caucasian population. Mol Genet Metab 104: 457-469.
  3. Rocca-Serra P, Bellaousov S, Birmingham A,Chen C, Cordero Pablo, Das R, Davis-Neulander L, Duncan C, Halvorsen M, Knight R, Leontis NB, Mathews DH, Ritz J, Stombaugh J, Weeks KM, Zirbel CL,,Laederach A (2011). Sharing and archiving nucleic acid structure mapping data. RNA 17: 1204-1212.
  4. Halvorsen M, Martin JS, Broadaway S, Laederach A. (2010). Disease-Associated Mutations That Alter the RNA Structural Ensemble. PLoS Genet 6(8): e1001074. doi:10.1371/journal.pgen.1001074

        *    Both authors contributed equally to the listed publication

 

 

Yujun Han
 Yujun Han
 
Yujun received his Ph.D from University of Georgia and he joined CHGV in September 2010. He focuses on the study of transposable elements and human genome variations.
Selected Publications
 
  1. MITE-Hunter: a program for discovering miniature inverted-repeat transposable elements from genomic sequences. Han Y and Wessler. S.R. Nucleic Acids Research. (2010)
  2. TARGeT: a web-based pipeline for retrieving and characterizing gene and transposable element families from genomic sequences. Han, Y., Burnette, J.M. III and Wessler, S.R. Nucleic Acids Research. (2009)
  3. ReAS: Recovery of Ancestral Sequences for Transposable Elements from the Unassembled Reads of a Whole Genome Shotgun. Li R, Ye J, Li S, Wang J, Han Y, Ye C, Wang J, Yang H, Yu J, Wong GK, Wang J. PLoS Comput Biol. (2005)
  4. Applications of the double-barreled data in whole-genome shotgun sequence assembly and analysis.
  5. Han Y, Ni P, Li H, Ye J, Hu J, Chen C, Huang X, Cong L, Li G, Wang J, Gu X, Yu J, Li S. Sci China C Life Sci. (2005)
  6. RePS: A Sequence Assembler That Masks Exact Repeats Identified from the Shotgun Data.
  7. Wang J, Wong GK, Ni P, Han Y, Huang X, Zhang J, Ye C, Zhang Y, Hu J, Zhang K, Xu X, Cong L, Lu H, Ren X, Ren X, He J, Tao L, Passey DA, Wang J, Yang H, Yu J, Li S. Genome Research. (2002) 

 

Yujun Han
Francesca La Carpia
 
Francesca received her Ph.D in Molecular Genetics at Universita’ Cattolica del Sacro Cuore of Rome in January 2014. She Joined CHGV in June 2014. Her research focuses on characterizing functional consequences of identified genetic variants in epilepsy, using genome editing of stem cells and neural differentiation.

 

 

Slavé Petrovski

Slavé received his PhD from University of Melbourne, Australia and he joined the CHGV for the second time in May 2012. He focuses on the study of population genetics and the role of genome variation in disease and treatment outcomes.

 

 Selected Publications

  1. Petrovski S, Wang Q, Heinzen, EL, Allen AS, Goldstein DB. Genic Intolerance to Functional Variation and the Interpretation of Personal Genomes. PLOS Genetics 2013 (doi: 10.1371/journal.pgen.1003709).
  2. Epi4K Consortium. De novo mutation in epileptic encephalopathies. Nature 2013 (doi: doi:10.1038/nature12439).
  3. Goldstein DB, Allen A, Keebler J, Margulies E, Petrou S, Petrovski S, Sunyaev S. Sequencing studies in human genetics: design and interpretation. Nature Review Genetics  2013; 14,460–470; doi:10.1038/nrg3455
  4. Speed D*, Hoggart C*, Petrovski S*, Tachmazidou I*, Jorgensen A, De Iorio M, Todaro M, Coffey A, Smith D, Smith P, Jackson M, Cooper P, Kellett M, Howell S, Sills G, Chadwick D, Pirmohamed M, Bentley D, Scheffer I, Berkovic S, Balding D, Marson A, Palotie A, O’Brien TJ, Johnson MR. Genetic determinants for remission of seizures in newly treated epilepsy: a prospective cohort genome-wide association study. Human Molecular Genetics 2013 (in press).
  5. Bayly J, Carino J, Petrovski S, Smit M, Fernando DA, Vinton A, Yan B, Gubbi JR, Palaniswami MS, O'Brien TJ. Time-frequency mapping of the rhythmic limb movements distinguishes convulsive epileptic from psychogenic nonepileptic seizures. Epilepsia 2013 [doi: 10.1111/epi.12207].
  6. Petrovski S, Kwan P. Unravelling the genetics of common epilepsies: approaches, platforms, caveats. Epilepsy & Behaviour 2012 [doi: 10.1016/j.yebeh.2012.09.007].
  7. Hakami T, Todaro M, Petrovski S, MacGregor L, Velakoulis D, Tan M, Matkovic Z, Gorelik A, Liew D, Yerra R, O’Brien TJ. Substitution Monotherapy with Levetiracetam Versus Older AEDs: A RCT. Archives of Neurology 2012; Sep 3:1-9. [doi: 10.1001/archneurol.2012.2203]
  8. Zhu Q*, Ge D*, Maia J, Zhu M, Petrovski S, Dickson SP, Heinzen EL, Shianna KV, Goldstein DB. A genome-wide comparison of the functional properties of rare and common genetic variants in humans. AJHG 2011; 88(4): 458 – 468.
  9. Petrovski S*, Fellay J*, Shianna KV, Carpenetti N, Kumwenda J, Kamanga G, Kamwendo DD, Letvin NL, McMichael AJ, Haynes BF, Cohen MS, Goldstein DB. Common Human Genetic Variants and HIV-1 Susceptibility: A Genome-Wide Survey in a Homogeneous African Population. AIDS 2011; 24(4): 513-518.
  10. Petrovski S, Szoeke CEI, Jones NC, Salzberg MR, Sheffield LJ, Huggins RM, O’Brien TJ. Neuropsychiatric Symptomatology Predicts Seizure Recurrence In Newly Treated Patients. Neurology 2010; 75: 1015-1021.
  11. Miller H, Clarke S, Lane S, Lonie A, Lazaridis D, Petrovski S, Jones O. Predicting customer behaviour: The University of Melbourne's KDD Cup report. JMLR 2009; Volume 7 Workshop and Conference Proceedings: 45-55

 

 

Patrick Shea

Patrick received his Ph.D. in human genetics from the University of Pittsburgh.  He joined the Center for Human Genome Variation in 2011, following a two year fellowship in infectious disease.  His research is focused on understanding how human genetic variation contributes to differences in infectious disease susceptibility and pathogenesis.

Selected Publications

  1. Shea PR, Ewbank AL, Gonzalez-Lugo JH, Martagon-Rosado AJ, Martinez-Gutierrez JC, Rehman HA, Serrano-Gonzalez M, Fittipaldi N, Beres SB, Flores AR, Low DE, Willey BM, Musser JM. Group A Streptococcus emm Gene Types in Pharyngeal Isolates, Ontario, Canada, 2002-2010. Emerg Infect Dis. 2011 Nov;17(11):2010-7.
  2. Carroll RK, Shelburne SA 3rd, Olsen RJ, Suber B, Sahasrabhojane P, Kumaraswami M, Beres SB, Shea PR, Flores AR, Musser JM. Naturally occurring single amino acid replacements in a regulatory protein alter streptococcal gene expression and virulence in mice. J Clin Invest. 2011 May;121(5):1956-68.
  3. Shea PR, Beres SB, Flores AR, Ewbank AL, Gonzalez-Lugo JH, Martagon-Rosado AJ, Martinez-Gutierrez JC, Rehman HA, Serrano-Gonzalez M, Fittipaldi N, Ayers SD, Webb P, Willey BM, Low DE, Musser JM. Distinct signatures of diversifying selection revealed by genome analysis of respiratory tract and invasive bacterial populations. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5039-44.
  4. Shea PR, Virtaneva K, Kupko JJ 3rd, Porcella SF, Barry WT, Wright FA, Kobayashi SD, Carmody A, Ireland RM, Sturdevant DE, Ricklefs SM, Babar I, Johnson CA, Graham MR, Gardner DJ, Bailey JR, Parnell MJ, Deleo FR, Musser JM. Interactome analysis of longitudinal pharyngeal infection of cynomolgus macaques by group A Streptococcus. Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4693-8.
  5. Beres SB, Carroll RK, Shea PR, Sitkiewicz I, Martinez-Gutierrez JC, Low DE, McGeer A, Willey BM, Green K, Tyrrell GJ, Goldman TD, Feldgarden M, Birren BW, Fofanov Y, Boos J, Wheaton WD, Honisch C, Musser JM. Molecular complexity of successive bacterial epidemics deconvoluted by comparative pathogenomics. Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4371-6.
  6. Shea PR, Ishwad CS, Bunker CH, Patrick AL, Kuller LH, Ferrell RE. RNASEL and RNASEL-inhibitor variation and prostate cancer risk in Afro-Caribbeans. Prostate. 2008 Mar 1;68(4):354-9.
  7. Shea PR, Ferrell RE, Patrick AL, Kuller LH, Bunker CH. ELAC2 and prostate cancer risk in Afro-Caribbeans of Tobago. Hum Genet. 2002 Oct;111(4-5):398-400. Epub 2002 Aug 21.

 

Mingfu Zhu

Xiaodi Yao
 
 
Xiaodi received her Ph.D in Biochemistry, Cell and Developmental Biology at Emory University in 2012. She joined CHGV in July 2013. Her research focuses on functional analysis of variants associated with human diseases.
 

 Selected Publications

  1. Yao, X., Gross, C., Xing, L., and Bassell, G.J. miR-324-5p regulates the expression of A-type potassium channel Kv4.2. (manuscript in preparation)
  2. Xing, L., Yao, X., Williams, K.R., and Bassell, G.J. (2012). Negative regulation of RhoA translation and signaling by hnRNP-Q1 affects cellular morphogenesis. Mol Biol Cell 23, 1500-1509.
  3. Swanger, S.A., Yao, X., Gross, C., and Bassell, G.J. (2011). Automated 4D analysis of dendritic spine morphology: applications to stimulus-induced spine remodeling and pharmacological rescue in a disease model. Mol Brain 4, 38.
  4. Gross, C.*, Yao, X.*, Pong, D.L., Jeromin, A., and Bassell, G.J. (2011). Fragile x mental retardation protein regulates protein expression and mRNA translation of the potassium channel kv4.2. J Neurosci 31, 5693-5698. (*contributed equally to this work)
  5. Muddashetty, R.S., Nalavadi, V.C., Gross, C., Yao, X., Xing, L., Laur, O., Warren, S.T., and Bassell, G.J. (2011). Reversible inhibition of PSD-95 mRNA translation by miR-125a, FMRP phosphorylation, and mGluR signaling. Mol Cell 42, 673-688.
  6. Gross, C., Nakamoto, M.*, Yao, X.*, Chan, C.B., Yim, S.Y., Ye, K., Warren, S.T., and Bassell, G.J. (2010). Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome. J Neurosci 30, 10624-10638. (*contributed equally to this work)

 

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